This lecture will detail the creation of ultrasensitive sensors based on electronically active conjugated polymers (CPs) and carbon nanotubes (CNTs). A central concept that a single nano- or molecular-wire spanning between two electrodes would create an exceptional sensor if binding of a molecule of interest to it would block all electronic transport. The use of molecular electronic circuits to give signal gain is not limited to electrical transport and CP-based fluorescent sensors can provide ultratrace detection of chemical vapors via amplification resulting from exciton migration. Nanowire networks of CNTs provide for a practical approximation to the single nanowire scheme. High sensitivity needs to be paired with high selectivity to create sensors with real-world utility. To this end, I will detail a number of transduction mechanisms that make use of receptors (biological and synthetic), selective catalytic processes, and the unique characteristics of the analytes of interest. Transduction events that result in changes in the Fermi levels of materials are particularly effective. Analyte triggered oxidation can create devices, including lateral flow assays (LFAs) based on CPs, that display nearly 1,000,000% change in resistivity. New generations electronic LFAs will be detailed, which when combined with radio frequency identification (RFID) technology creates wireless, highly sensitive, sensors for use in medical diagnostics and environmental monitoring.
Timothy M. Swager is the John D. MacArthur Professor of Chemistry at the Massachusetts Institute of Technology. A native of Montana, he received a BS from Montana State University in 1983 and a Ph.D. from the California Institute of Technology in 1988. After a postdoctoral appointment at MIT he was on the chemistry faculty at the University of Pennsylvania 1990-1996 and returned to MIT in 1996 as a Professor of Chemistry and served as the Head of Chemistry from 2005-2010. He has published more than 500 peer-reviewed papers and more than 120 issued/pending patents. Swager’s honors include: Election to the National Academy of Sciences, an Honorary Doctorate from Montana State University, National Academy of Inventors Fellow, The Pauling Medal, The Lemelson-MIT Award for Invention and Innovation, Election to the American Academy of Arts and Sciences, The American Chemical Society Award for Creative Invention, The American Chemical Society Award in Polymer Chemistry, The Christopher Columbus Foundation Homeland Security Award, and The Carl S. Marvel Creative Polymer Chemistry Award (ACS).
Swager’s research interests are in design, synthesis, and study of organic-based electronic, sensory, energy harvesting, membrane, high-strength, liquid crystalline, and colloid materials. His liquid crystal designs demonstrated shape complementarity to generate specific interactions between molecules and includes fundamental mechanisms for increasing liquid crystal order by a new mechanism referred to as minimization of free volume. Swager’s research in electronic polymers has been mainly directed at the demonstration of new conceptual approaches to the construction of sensory materials. These methods are the basis of the FidoTM explosives detectors (FLIR Systems Inc), which have the highest sensitivity of any explosives sensor. Other areas actively investigated by the Swager group include radicals for dynamic nuclear polarization, applications of nano-carbon materials, organic photovoltaic materials, polymer actuators, separation membranes, and luminescent molecular probes for medical diagnostics. He has founded five companies (DyNuPol, Iptyx, PolyJoule, C2 Sense and Xibus Systems) and has served on a number of corporate and government boards.